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Related Concept Videos

Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

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Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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TRAIL in cancer therapy: present and future challenges.

Delphine Mérino1, Najoua Lalaoui, Alexandre Morizot

  • 1INSERM, U866, Dijon, F-21079, France.

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TNF-related apoptosis-inducing ligand (TRAIL) shows promise for selective cancer cell death induction with minimal toxicity. Further research into TRAIL mechanisms and cancer cell resistance is crucial for effective clinical application.

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Published on: December 9, 2015

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • TNF-related apoptosis-inducing ligand (TRAIL) identified in 1995.
  • TRAIL selectively induces cancer cell death with low in vivo toxicity.
  • Preclinical evaluations highlight TRAIL's antitumoural potential.

Purpose of the Study:

  • To review recent advances in TRAIL signal transduction.
  • To discuss challenges in TRAIL-based cancer therapy.
  • To understand mechanisms of TRAIL selectivity and cancer cell resistance.

Main Methods:

  • Literature review of TRAIL signal transduction pathways.
  • Analysis of preclinical and clinical TRAIL therapy data.
  • Discussion of cancer cell escape mechanisms from TRAIL-induced apoptosis.

Main Results:

  • TRAIL exhibits selective cancer cell apoptosis induction.
  • Understanding TRAIL mechanisms and cancer resistance is limited.
  • TRAIL's safety profile supports its therapeutic interest.

Conclusions:

  • Further elucidation of TRAIL signaling is needed.
  • Overcoming cancer cell resistance is key for clinical success.
  • TRAIL-based therapies require optimized strategies for effective cancer treatment.