Primary B-cell lymphoma presenting as bilateral ear lobule swelling

Area of Science:

• Oncology
• Hematology
• Dermatopathology

Background:

• Lymphomas, particularly B-cell types, can present with extranodal manifestations.
• Ear lobule involvement by lymphoma is exceptionally uncommon.
• Primary lymphomas require thorough investigation to exclude systemic disease.

Observation:

• A 56-year-old male presented with a year-long history of bilateral, painless ear lobule swelling.
• Excision biopsy of the affected tissue confirmed the presence of B-cell lymphoma.
• Comprehensive systemic evaluation ruled out secondary involvement or disseminated disease.

Findings:

• This case represents the first reported instance of primary B-cell lymphoma exclusively involving bilateral ear lobules.
• The histological diagnosis was confirmed as B-cell lymphoma.
• Systemic workup excluded other potential causes or widespread lymphoma.

Implications:

• Clinicians should consider rare B-cell lymphomas in the differential diagnosis of unexplained ear lobule masses.
• This case expands the known spectrum of extranodal lymphoma presentations.
• Awareness of such rare presentations is crucial for timely diagnosis and appropriate patient management.