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Rapidly progressive glomerulonephritis associated with nontuberculous mycobacteria
Shwu-Jiuan Chen1, Yao-Ko Wen, Mei-Ling Chen
1Division of Nephrology, Department of Medicine, Changhua Christian Hospital, Changhua, Taiwan, ROC.
Journal of the Chinese Medical Association : JCMA
|October 3, 2007
Summary
Nontuberculous mycobacteria (NTM) pulmonary disease reactivation can cause severe kidney injury. This case highlights the first report of rapidly progressive glomerulonephritis linked to NTM infection, emphasizing prompt treatment for recovery.
Area of Science:
- Nephrology
- Pulmonology
- Infectious Diseases
Background:
- Nontuberculous mycobacteria (NTM) pulmonary disease is a chronic condition.
- Acute renal failure and hemoptysis are serious presenting symptoms.
Observation:
- A 72-year-old woman presented with hemoptysis and acute renal failure.
- Kidney biopsy revealed immune complex-mediated glomerulonephritis with crescents.
- Mycobacterium avium was identified in sputum and lung biopsy cultures.
Findings:
- Reactivated NTM pulmonary disease was diagnosed.
- Rapidly progressive glomerulonephritis was associated with NTM infection.
- Treatment with antituberculous drugs and clarithromycin improved pulmonary and renal function.
Implications:
- This is the first reported case of rapidly progressive glomerulonephritis associated with NTM infection.
- Early diagnosis and treatment of NTM infection are crucial for managing renal complications.
- Highlights the potential systemic impact of NTM pulmonary disease.
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