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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Cerebrospinal fluid distribution of ibuprofen after intravenous administration in children

Hannu Kokki1, Elina Kumpulainen, Marko Lehtonen

  • 1Department of Pharmacology and Toxicology, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland. hannu.kokki@kuh.fi

Pediatrics
|October 3, 2007
PubMed

Insights

Ibuprofen readily penetrates the cerebrospinal fluid in children, reaching peak levels within 30-40 minutes after a 10 mg/kg intravenous dose. This study quantifies ibuprofen

Area of Science:

  • Pediatric Pharmacology
  • Neuroscience
  • Pain Management

Background:

  • Ibuprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID) for children.
  • NSAIDs affect both peripheral and central nervous systems.
  • Cerebrospinal fluid (CSF) penetration of ibuprofen is established in adults but not children.

Purpose of the Study:

  • To investigate ibuprofen's penetration into the cerebrospinal fluid (CSF) in pediatric patients.
  • To evaluate ibuprofen's plasma concentration for analgesia following pediatric inguinal surgery.

Main Methods:

  • 36 children (3 months–12 years) received a single IV ibuprofen dose (10 mg/kg).
  • Paired CSF and blood samples were collected 10 minutes to 8 hours post-injection.
  • Additional blood samples were taken from surgical patients experiencing pain.

Main Results:

  • Ibuprofen was detected in all CSF and plasma samples.
  • CSF ibuprofen concentrations ranged from 15–541 µg/L, peaking at 30–38 minutes.
  • Post-30 minutes, CSF ibuprofen levels exceeded unbound plasma concentrations.

Conclusions:

  • Ibuprofen demonstrates ready penetration into the CSF of children.
  • Peak CSF concentrations are achieved 30–40 minutes after IV administration.
  • Effective plasma analgesic concentrations for post-operative pain range from 10–25 mg/L.
Abstract

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