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Updated: Jul 11, 2026

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
Published on: October 14, 2021
Hormonal replacement therapy in women with Parkinson disease and levodopa-induced dyskinesia: a crossover trial
Alessandra Nicoletti1, Gennarina Arabia, Pierfrancesco Pugliese
1Department of Neurosciences, University of Catania, Via Santa Sofia no. 78, 95123 Catania, Italy.
Abstract:
Eleven postmenopausal women with Parkinson disease and levodopa-induced peak-dose dyskinesias underwent a double-blind, placebo-controlled, crossover study. The active treatment consisted of estrogen replacement therapy for 12 weeks, followed by medroxyprogesterone acetate for 2 weeks. Estrogen replacement therapy-medroxyprogesterone acetate administration significantly improved peak-dose dyskinesia without worsening motor disability, thus suggesting a possible benefit on dyskinesias in postmenopausal women with Parkinson disease.
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