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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

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Published on: September 26, 2013

Systemic IL-17 after severe injuries.

Thomas M Frangen1, Denise Bogdanski, Christian Schinkel

  • 1Berufsgenossenshaftliches Universitätsklinikum Bergmannsheil GmbH, Department of Surgery, Ruhr-University Bochum, Bochum, Germany.

Shock (Augusta, Ga.)
|October 3, 2007
PubMed
Summary

Interleukin-17 (IL-17) is not a reliable marker for immune dysfunction after polytrauma. This study found systemic IL-17 levels were mostly normal in patients, suggesting it

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Area of Science:

  • Immunology
  • Trauma Research
  • Cytokine Signaling

Background:

  • Interleukin-17 (IL-17) is a key cytokine in inflammation, linking T-cell activation to neutrophil response.
  • The role of IL-17 in immune dysfunction following polytrauma remains unclear.
  • IL-17 is produced by T helper 17 (TH17) cells, a recently identified T-cell subset.

Purpose of the Study:

  • To investigate the systemic concentration and potential role of IL-17 in polytraumatized patients.
  • To determine if IL-17 can serve as a pathophysiological or predictive marker post-polytrauma.

Main Methods:

  • Retrospective analysis of daily systemic IL-17 and IL-6 concentrations in 71 polytraumatized patients using enzyme-linked immunosorbent assay (ELISA).
  • Patients were categorized into groups based on IL-17 plasma levels (normal vs. elevated).
  • Longitudinal analysis included peripheral blood mononuclear cell (PBMC) stimulation assays (ELISPOT, flow cytometry) in one patient with a history of high IL-17.

Main Results:

  • Systemic IL-17 increase was detected in only 6% of patients; 94% showed levels within the normal range.
  • Elevated IL-17 (>45 pg/mL for 3 consecutive days) was observed in a small subgroup, particularly those with blunt chest/abdominal trauma and lung contusion.
  • One patient with previously high IL-17 levels showed normal systemic IL-17 but elevated IL-17-producing cells in PBMCs years later.

Conclusions:

  • Systemic IL-17 is not a suitable pathophysiological or predictive marker in the context of polytrauma.
  • Highly elevated IL-17 in specific patients might be linked to an increased number of TH17 cells, requiring further investigation.
  • The study highlights the complexity of IL-17 involvement in post-polytrauma immune responses.