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Updated: Jul 11, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Synthesis of novel nitro-substituted triaryl pyrazole derivatives as potential estrogen receptor ligands
Fotini Naoum1, Konstantinos M Kasiotis, Prokopios Magiatis
1Chemistry Laboratory, Agricultural University of Athens, Iera odos 75, Athens 11855, Greece.
Abstract:
Novel tetrasubstituted pyrazole derivatives bearing a nitro substituent on their A-phenol ring were synthesized and their binding affinity towards the estrogen receptor (ER) subtypes ERalpha and ERbeta was determined. Among compounds tested, the 2-nitrophenol derivative 5c was found to bind satisfactorily to both estrogen receptor subtypes (RBAalpha=5.17 and RBAbeta=3.27). In general, the introduction of a nitro group into the A ring of these compounds was found to benefit their ERbeta binding abilities.
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