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Updated: Jul 11, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
An efficient and rapid synthetic route to biologically interesting pyranochalcone natural products
Yong Rok Lee1, Xue Wang, Likai Xia
1School of Chemical Engineering and Technology, Yeungnam University, Gyeongsan 712-749, Korea. yrlee@yu.ac.kr
Abstract:
An efficient and concise total synthesis of naturally occurring pyranochalcones was achieved from readily available 2,4-dihydroxyacetophenone and 2,4-dihydroxy-6-methoxyacetophenone. The key steps in the synthetic strategy were ethylenediamine diacetate-catalyzed benzopyran formation and aldol reactions.
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