Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rhabdomyolysis.

W H Bagley1, H Yang, K H Shah

  • 1Department of Emergency Medicine, St. Luke's-Roosevelt Hospital, University Hospital of Columbia Physicians & Surgeons, New York, NY 10025, USA.

Internal and Emergency Medicine
|October 3, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Helicobacter pylori in the oral cavity reflects handling of contaminants but not gastric infection.

Digestion·1999
Same author

Differential expression of a novel seven transmembrane domain protein in epididymal fat from aged and diabetic mice.

Endocrinology·1999
Same author

Streptozotocin dose-response curve in tilapia, a glucose-responsive teleost fish.

General and comparative endocrinology·1999
Same author

[Studies on effects of yttrium chloride and praseodymium chloride on frequency of micronucleus in human blood lymphocytes].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·1999
Same author

[Effects of aluminum on neurobehavioral function and metabolism of monoamine neurotransmitter].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·1999
Same author

Variation among cell types in the signaling pathways by which IGF-I stimulates specific cellular responses.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·1999
Same journal

Utility of the diaphragm assessment in acute decompensated heart failure: a case series and a proof-of-concept study.

Internal and emergency medicine·2026
Same journal

When Rosai-Dorfman meets autoimmunity.

Internal and emergency medicine·2026
Same journal

Hypocholesterolemia as a predictor of mortality in infective endocarditis.

Internal and emergency medicine·2026
Same journal

Correction: Diagnostic accuracy and clinical impact of internist-performed point-of-care ultrasound in atrial fibrillation: a multicenter study.

Internal and emergency medicine·2026
Same journal

Managing emergency department overcrowding: analysis through a dynamic simulation model of the impact of organizational variables on emergency department processes.

Internal and emergency medicine·2026
Same journal

Gunshot-induced carotid artery injury: exploring other determined aetiologies of stroke.

Internal and emergency medicine·2026
See all related articles

Rhabdomyolysis, a skeletal muscle breakdown syndrome, is diagnosed by elevated creatine phosphokinase (CPK). Early, aggressive intravenous fluid resuscitation offers a favorable prognosis, though mortality remains up to 8%.

Area of Science:

  • Medical Science
  • Pathophysiology
  • Clinical Medicine

Background:

  • Rhabdomyolysis is a critical condition characterized by skeletal muscle breakdown.
  • It results from diverse causes including diseases, injuries, medications, and toxins.
  • Muscle damage stems from direct injury or metabolic energy imbalances.

Purpose of the Study:

  • To provide a comprehensive review of rhabdomyolysis.
  • To elucidate its pathophysiology, diagnosis, complications, and treatment.
  • To highlight current understanding and treatment controversies.

Main Methods:

  • Diagnosis relies on elevated serum creatine phosphokinase (CPK) levels.
  • Clinical presentation and laboratory findings are key diagnostic indicators.

Related Experiment Videos

  • Review of existing literature on causes, diagnosis, and management.

    • Main Results:

    • Rhabdomyolysis can lead to acute renal failure, compartment syndrome, and cardiac dysrhythmias.
    • Aggressive intravenous fluid (IVF) resuscitation is the primary treatment.
    • Adjunctive therapies like urine alkalinization and diuretics lack strong evidence from randomized trials.

    Conclusions:

    • Early and aggressive IVF is crucial for favorable outcomes and renal function recovery.
    • Despite treatment, rhabdomyolysis carries a significant mortality risk of up to 8%.
    • Further research is needed to establish definitive recommendations for adjunctive therapies.