Related Experiment Video
Updated: Jul 11, 2026

Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
Before we get started: what is a cough?
1Department of Critical Care, University of Florence, Viale G B Morgagni, Florence, Italy. g.fontana@dac.unifi.it
Abstract:
Cough is an airway defensive reflex consisting of an inspiratory phase followed by a forced expiratory effort initially against a closed glottis, followed by active glottal opening and rapid expiratory flow. The expiration reflex (ER) differentiates from cough for the lack of a preparatory inspiration. The reflexes subserve different functions: cough will clear the lower airways from debris and mucus, while the expiration reflex will prevent aspiration. Clinically, a cough epoch is a sequence of motor acts resulting from a combination of true coughs and ERs that need to be accurately identified and measured for adequate quantitative description.
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