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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
Primary pulmonary malignant peripheral nerve sheath tumor: a case report
Takashi Tashiro1, Chisato Kawakita, Chikako Takai
1Pathology Division, Hyogo Prefectural Kakogawa Hospital, Hyogo, Japan. kenkako1@gold.ocn.ne.jp
Acta Cytologica
|October 4, 2007
Summary
Cytologic features of primary pulmonary malignant peripheral nerve sheath tumor (MPNST) are described for the first time. Multinucleated giant cells and S-100 positivity aid in diagnosing this rare lung cancer.
Area of Science:
- Pulmonology
- Oncology
- Cytopathology
Background:
- Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma.
- Histologic features of MPNST are known, but cytologic descriptions of primary pulmonary MPNST are lacking in literature.
Observation:
- A case of primary pulmonary MPNST in a 78-year-old male is presented.
- A 12 mm nodular lesion in the right upper lung lobe was identified.
- Frozen section revealed a malignant neoplasm, not otherwise specified.
Findings:
- Imprint cytology showed small cellular aggregates and discohesive neoplastic cells with malignant features.
- Histology revealed spindle cells with pleomorphic nuclei, multinucleated tumor giant cells, and >25 mitoses per 10 HPF.
- Tumor cells were positive for vimentin and S-100, with a Ki-67 labeling index of 10%.
Implications:
- MPNST exhibits varied cytomorphology with nuclear atypia and lack of definite differentiation.
- The presence of multinucleated neoplastic giant cells with S-100 immunopositivity can aid in the accurate diagnosis of primary pulmonary MPNST.
