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Updated: Jul 11, 2026

Analysis of the Development of a Morphological Phenotype as a Function of Protein Concentration in Budding Yeast
Published on: March 24, 2010
Induction of DAN/TIR yeast cell wall mannoprotein genes in response to high hydrostatic pressure and low temperature
1Extremobiosphere Research Center, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), 2-15 Natsushima-cho, Yokosuka 237-0061, Japan. abef@jamstec.go.jp
Abstract:
Global transcriptional profiles of Saccharomyces cerevisiae were studied following changes in growth conditions to high hydrostatic pressure and low temperature. These profiles were quantitatively very similar, encompassing 561 co-upregulated genes and 161 co-downregulated genes. In particular, expression of the DAN/TIR cell wall mannoprotein genes, which are generally expressed under hypoxia, were markedly upregulated by high pressure and low temperature, suggesting the overlapping regulatory networks of transcription. In support of the role of mannoproteins in cell wall integrity, cells acquired resistance against treatment with SDS, Zymolyase and lethal levels of high pressure when preincubated under high pressure and low temperature.
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