Novel scaffold for cathepsin K inhibitors
Naoki Teno1, Takahiro Miyake, Takeru Ehara
1Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki, Japan. naoki.teno@novartis.com
Bioorganic & Medicinal Chemistry Letters
|October 4, 2007
Abstract:
Pyrrolopyrimidine, a novel scaffold, allows to adjust interactions within the S3 subsite of cathepsin K. The core intermediate 10 facilitated the P3 optimization and identified highly potent and selective cathepsin K inhibitors 11-20.


