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Updated: Jul 11, 2026

An Optimized Protocol for the Efficient Radiolabeling of Gold Nanoparticles by Using a 125I-labeled Azide Prosthetic Group
Published on: October 10, 2016
Novel synthetic ligands for targeted PET imaging and radiotherapy of copper
Hyun-Soon Chong1, Santosh Mhaske, Mai Lin
1Chemistry Division, Biological, Chemical, and Physical Science Department, Illinois Institute of Technology, 3101 S. Dearborn Street, Chicago, IL 60616, USA. Chong@iit.edu
Abstract:
Novel ligands, NBEA, NBPA, NETA, NE3TA, and NE3TA-Bn, were synthesized and evaluated as potential chelators of copper radioisotopes for use in targeted positron emission tomography (PET) imaging or radiation therapy. The new ligands were radiolabeled with (64)Cu, and in vitro stability of the radiolabeled complexes was assessed in rat serum. Serum stability results suggest that among the ligands tested, NETA, NE3TA, and NE3TA-Bn form stable complexes with (64)Cu.

