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Related Experiment Video

Updated: Jul 11, 2026

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images

Published on: November 15, 2024

Proximal calciphylaxis treated with calcimimetic 'Cinacalcet'.

Ismail A Mohammed¹, Vashisht Sekar, Abdullah J Bubtana

¹Department of Renal Medicine, Manchester Royal Infirmary, Manchester, UK. i.mohammed@doctors.net.uk

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association

|October 4, 2007

Summary

Calciphylaxis, a rare condition in end-stage renal failure patients, causes skin tissue death. A small dose of Cinacalcet, a calcimimetic, effectively treated a severe case, offering a potential new therapeutic option.

Related Experiment Videos

Last Updated: Jul 11, 2026

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images

Published on: November 15, 2024

Area of Science:

Nephrology
Dermatology
Vascular Medicine

Background:

Calciphylaxis is a rare, severe condition in end-stage renal failure (ESRF) patients.
It involves painful skin necrosis and ischemia, posing significant management challenges.
Current treatments are limited, with parathyroidectomy showing some efficacy.

Observation:

A case of severe proximal calciphylaxis was observed.
The patient had end-stage renal failure.

Findings:

Treatment with a low dose of the calcimimetic agent Cinacalcet was administered.
The patient showed a positive response to Cinacalcet therapy.

Implications:

Cinacalcet may represent a novel therapeutic strategy for calciphylaxis.
Further research into calcimimetic agents for calciphylaxis is warranted.
This case highlights a potential treatment avenue for this challenging condition.