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Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
Acidaminococcus intestini sp. nov., isolated from human clinical samples
Estelle Jumas-Bilak1, Jean-Philippe Carlier2, Hélène Jean-Pierre3
1Université Montpellier 1, Faculté de Pharmacie, Laboratoire de Bactériologie-Virologie, 15 Avenue Charles Flahault, BP 14491, 34060 Montpellier Cedex 5, France.
Summary
A new anaerobic coccus, Acidaminococcus intestini sp. nov., was discovered in human clinical samples. This novel bacterium is genetically and phenotypically distinct from Acidaminococcus fermentans.
Area of Science:
- Microbiology
- Bacteriology
- Genomics
Background:
- Gram-negative, anaerobic cocci are clinically relevant bacteria.
- The genus Acidaminococcus includes species with known human pathogens.
Purpose of the Study:
- To characterize and classify novel bacterial strains isolated from human clinical samples.
- To determine the phylogenetic and genotypic relationship of these isolates to existing Acidaminococcus species.
Main Methods:
- Isolation and cultivation of bacterial strains from human clinical samples.
- 16S and 23S rRNA gene sequencing and phylogenetic analysis.
- Phenotypic characterization including enzymic activity and metabolic end products.
Main Results:
- Eleven strains of an unknown Gram-negative, anaerobic coccus were identified.
- Sequence analysis revealed distinct phylogenetic clustering separate from Acidaminococcus fermentans.
- Unique enzymic profiles and propionic acid production differentiated the novel species.
Conclusions:
- The data support the proposal of a new species, Acidaminococcus intestini sp. nov.
- This discovery expands the known diversity within the Acidaminococcus genus.
- Acidaminococcus intestini represents a novel finding in human clinical microbiology.
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