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Related Experiment Video

Updated: Jul 11, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Primary hyperparathyroidism is associated with increased circulating bone marrow-derived progenitor cells.

Stefan Brunner¹, Hans Diogenes Theiss, Alfons Murr

¹Medizinische Klinik und Poliklinik I, Klinikum Grosshadern, Marchioninistr. 15, 81377 Munich, Germany.

American Journal of Physiology. Endocrinology and Metabolism

|October 4, 2007

Summary

Parathyroid hormone (PTH) mobilizes bone marrow-derived progenitor cells (BMCs) in primary hyperparathyroidism (PHPT). Increased circulating BMCs in PHPT patients normalized after surgery, suggesting a direct role for PTH in stem cell release.

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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

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Last Updated: Jul 11, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

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Published on: July 14, 2023

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

Area of Science:

Endocrinology
Hematology
Stem Cell Biology

Background:

Parathyroid hormone (PTH) supports bone marrow progenitor cell survival.
Progenitor cell release contributes to neovascularization in various conditions.
The impact of primary hyperparathyroidism (PHPT) on progenitor cell mobilization is unknown.

Purpose of the Study:

To investigate the effect of PHPT on the mobilization of bone marrow-derived progenitor cells (BMCs).
To explore the relationship between PTH levels and circulating BMC subpopulations.
To assess the role of cytokines in PTH-mediated BMC mobilization.

Main Methods:

Prospective study of 22 PHPT patients and 10 controls.
Flow cytometry analysis of BMC subpopulations (endothelial, hematopoietic, CXCR4+ progenitor cells).
ELISA for cytokine serum levels (SCF, SDF-1, VEGF, EPO, G-CSF); PTH and hormone levels assessed.

Main Results:

PHPT patients showed significantly increased circulating BMCs and elevated SDF-1 and VEGF serum levels.
Circulating BMC levels normalized 16.7 months post-surgery.
PTH levels positively correlated with all analyzed BMC subpopulations, independent of cytokine levels.

Conclusions:

PTH directly mobilizes bone marrow-derived progenitor cells into peripheral blood.
PHPT is associated with increased circulating BMCs, suggesting a novel endocrine function of PTH.
This finding may have implications for understanding progenitor cell dynamics in endocrine disorders.