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Mycophenolate mofetil and atherosclerosis: results of animal and human studies

William Thomas Gibson1, Michael Reuben Hayden

  • 1Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4.

Annals of the New York Academy of Sciences
|October 4, 2007
PubMed

Insights

Mycophenolate mofetil (MMF) reduces blood vessel thickening in heart transplant patients. This immunosuppressant may also prevent atherosclerosis, a hardening of the arteries, in high-risk individuals.

Area of Science:

  • Immunology
  • Cardiology
  • Vascular Biology

Background:

  • Mycophenolate mofetil (MMF) is an immunosuppressant used in organ transplantation.
  • MMF has demonstrated benefits beyond preventing tissue rejection in cardiac transplant recipients.
  • Intimal thickening and cardiac allograft vasculopathy are reduced in patients treated with MMF compared to azathioprine.

Purpose of the Study:

  • To investigate the potential of MMF in preventing atherosclerosis.
  • To explore MMF's effects on diet-induced atherosclerosis in a hyperlipidemia rabbit model.

Main Methods:

  • Utilized a rabbit model of diet-induced hyperlipidemia.
  • Administered MMF to assess its impact on atherosclerotic development.

Main Results:

  • MMF treatment led to reduced atherosclerosis in the rabbit model.
  • Observed diminished intimal thickening and cardiac allograft vasculopathy in MMF-treated patients.

Conclusions:

  • MMF exhibits anti-atherosclerotic properties.
  • MMF shows promise as a preventive agent for atherosclerosis in at-risk human populations.

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