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Intravenous immunoglobulins in autoimmune and inflammatory diseases: a mechanistic perspective

Sophie Sibéril1, Sriramulu Elluru, Stéphanie Graff-Dubois

  • 1INSERM UMRS 872, Université René Descartes (Paris-5), Université Pierre et Marie Curie (UPMC Paris-6) 75006 Paris, France.

Annals of the New York Academy of Sciences
|October 4, 2007
PubMed

Initially used for the treatment of immunodeficiencies, intravenous immunoglobulins (IVIg) have increasingly been used as immunomodulatory agents in autoimmune and inflammatory disorders. The mode of action of IVIg is enigmatic, probably involving Fc-dependent and/or F(ab')2-dependent nonexclusive mechanisms of action. IVIg broadly interacts with the different components of the immune system: cytokines, complement, Fc receptors, and several cell surface immunocompetent molecules. IVIg has also an impact on effector functions of immune cells. These mechanisms of action of IVIg reflect the importance of natural antibodies in the maintenance of immune homeostasis. We discuss here the recent advances in the understanding of immunoregulatory effects of IVIg, and we pointed out the need for new strategies to overcome the predicted increasing worldwide shortage of IVIg.

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