Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The new anticoagulants.

William M Stone1, Britt H Tonnessen, Samuel R Money

  • 1Divisions of Vascular Surgery, Mayo Clinic Arizona, Scottsdale Arizona 85054, USA. Stone.William@mayo.edu

Perspectives in Vascular Surgery and Endovascular Therapy
|October 4, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hydration attenuates incidental iliac vein stenosis detected by magnetic resonance imaging in deliberately fasted asymptomatic individuals.

Journal of vascular surgery. Venous and lymphatic disorders·2026
Same author

Iatrogenic superior mesenteric artery dissection repaired with open septectomy and retrograde balloon control.

Journal of vascular surgery cases and innovative techniques·2026
Same author

The best of 2025 - peripheral and splanchnic aneurysms and mesenteric vascular disease.

Journal of vascular surgery cases and innovative techniques·2026
Same author

Risk Factors for Delirium after Abdominal Aortic Aneurysm Repair.

Annals of vascular surgery·2026
Same author

Frailty is associated with increased risk for upper arm arteriovenous fistula abandonment.

Journal of vascular surgery·2026
Same author

Smoking cessation after lower extremity revascularization in the Vascular Quality Initiative.

Journal of vascular surgery·2026
Same journal

Vernet's syndrome after carotid endarterectomy.

Perspectives in vascular surgery and endovascular therapy·2014
Same journal

25th silver anniversary of perspectives in vascular surgery and endovascular therapy.

Perspectives in vascular surgery and endovascular therapy·2014
Same journal

History of carotid surgery: from ancient greeks to the modern era.

Perspectives in vascular surgery and endovascular therapy·2013
Same journal

Proper hepatic artery reconstruction with gastroduodenal artery transposition during pancreaticoduodenectomy.

Perspectives in vascular surgery and endovascular therapy·2013
Same journal

Ruptured mycobacterial aneurysm of the carotid artery.

Perspectives in vascular surgery and endovascular therapy·2013
Same journal

Technique of implantation and bail-out maneuvers for endovascular fenestrated repair of juxtarenal aortic aneurysms.

Perspectives in vascular surgery and endovascular therapy·2013
See all related articles

New anticoagulants, including meta-pentasaccharides and direct Xa inhibitors, show promise for improved thromboembolic event treatment and deep venous thrombosis prophylaxis with fewer interactions and simpler dosing than warfarin.

Area of Science:

  • Pharmacology
  • Thrombosis Research
  • Drug Development

Background:

  • Current anticoagulants like warfarin have significant limitations including drug/food interactions and dosing difficulties.
  • Existing treatments include warfarin, heparin compounds, and direct thrombin inhibitors.

Purpose of the Study:

  • To review emerging anticoagulant therapies.
  • To highlight the advantages of novel anticoagulants over existing options.

Main Methods:

  • Review of ongoing clinical trials and studies for new anticoagulant classes.
  • Analysis of efficacy and safety data for meta-pentasaccharides, direct thrombin inhibitors, and direct Xa inhibitors.

Main Results:

  • Meta-pentasaccharides offer once-weekly subcutaneous dosing with efficacy comparable or superior to warfarin.

Related Experiment Videos

  • Oral direct thrombin inhibitors like Dabigatran show promise for DVT prophylaxis with minimal interactions.
  • Direct Xa inhibitors demonstrate equivalent or superior DVT prophylaxis, often with renal clearance.

    • Conclusions:

    • Novel anticoagulants are expected to offer significant advantages over current therapies.
    • Future anticoagulants will likely provide improved safety profiles and patient convenience.
    • Emerging drugs include oral direct thrombin and direct Xa inhibitors, and meta-pentasaccharides.