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Intravenous immunoglobulin therapy affects T regulatory cells by increasing their suppressive function

Aharon Kessel1, Hana Ammuri, Regina Peri

  • 1Division of Clinical Immunology, Bnai-Zion Medical Centre, Rappaport Faculty of Medicine, Technion, Haifa, Israel.

Journal of Immunology (Baltimore, Md. : 1950)
|October 4, 2007
PubMed
Summary

Intravenous immunoglobulin therapy (IVIg) boosts regulatory T cells (Treg), increasing TGF-beta, IL-10, and FoxP3 expression. This enhances Treg suppressive function, offering a new mechanism for IVIg in treating autoimmune diseases.

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