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Related Concept Videos

Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Meiosis II01:57

Meiosis II

Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each containing...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Meiosis II02:02

Meiosis II

Meiosis II entails cell division and segregation of the sister chromatids, resulting in the production of four unique haploid gametes. The steps for meiosis II are similar to mitosis, except that meiosis II occurs in haploid cells, whereas mitosis occurs in diploid cells.
The timing and cell division patterns of meiosis differ between males and females. In male meiosis, the centrosomes are part of the formation of the meiotic spindle. However, in oocytes, including that of humans, Drosophila,...
Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis And Cytokinesis01:35

Mitosis And Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...

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Related Experiment Video

Updated: May 17, 2026

A Cell Free Assay to Study Chromatin Decondensation at the End of Mitosis
11:04

A Cell Free Assay to Study Chromatin Decondensation at the End of Mitosis

Published on: December 19, 2015

Finishing mitosis, one step at a time.

Matt Sullivan1, David O Morgan

  • 1Department of Physiology, University of California, 600 16th Street, San Francisco, California 94158-2517, USA.

Nature Reviews. Molecular Cell Biology
|October 4, 2007
PubMed
Summary
This summary is machine-generated.

The order of events in late mitosis, including chromosome segregation and nuclear reformation, depends on the precise timing of cyclin-dependent kinase (Cdk) substrate dephosphorylation and anaphase-promoting complex (APC) substrate destruction.

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Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
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Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

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Related Experiment Videos

Last Updated: May 17, 2026

A Cell Free Assay to Study Chromatin Decondensation at the End of Mitosis
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Published on: December 19, 2015

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
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Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
07:14

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Mitosis is essential for cell division, ensuring accurate chromosome segregation.
  • Late mitotic stages involve spindle disassembly and chromosome packaging into daughter nuclei.
  • Progression through late mitosis is regulated by cyclin-dependent kinase (Cdk) dephosphorylation and anaphase-promoting complex (APC) substrate destruction.

Purpose of the Study:

  • To explore the hypothesis that the sequence of late mitotic events is controlled by the order of Cdk and APC substrate modifications.
  • To elucidate the regulatory mechanisms governing the completion of mitosis.

Main Methods:

  • This study is a discussion and hypothesis-driven review.
  • It focuses on the known molecular players and regulatory pathways in late mitosis.
  • No new experimental data was generated.

Main Results:

  • The hypothesis posits that the timing of Cdk substrate dephosphorylation and APC substrate destruction dictates the order of mitotic events.
  • This ordered regulation ensures the fidelity of cell division.

Conclusions:

  • The sequential modification of Cdk and APC substrates is a critical determinant of the order of events in late mitosis.
  • Understanding this order is key to comprehending the successful completion of cell division.