When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.

Heart sounds are generated by the turbulence in blood flow due to the closing of heart valves. These sounds are best perceived slightly away from the valves, where the blood flow disseminates the sound.
Auscultation is the process of listening to these internal body sounds using a stethoscope. The heart produces four types of sounds, but only two—S1 and S2—can usually be heard with a stethoscope.
S1, also known as the "lub" sound, is caused by the closure of atrioventricular (A-V) valves at the...

Sound waves, which are longitudinal waves, can be modeled as the displacement amplitude varying as a function of the spatial and temporal coordinates. As a column of the medium is displaced, its successive columns are also displaced. As the successive displacements differ relatively, a pressure difference with the surrounding pressure is created. The gauge pressure varies across the medium.
The pressure fluctuation depends on the difference in displacements between the successive points in the...

Sound waves can be thought of as fluctuations in the pressure of a medium through which they propagate. Since the pressure also makes the medium's particles vibrate along its direction of motion, the waves can be modeled as the displacement of the medium's particles from their mean position.
Sound waves are longitudinal in most fluids because fluids cannot sustain any lateral pressure. In solids, however, shear forces help in propagating the disturbance in the lateral direction as well. Hence,...

Many receptor binding ligands are hydrophilic; they do not cross the cell membrane but bind to cell-surface receptors. Thus, their message must be relayed by second messengers present in the cell cytoplasm. There are several second messenger pathways, each with its own way of relaying information. For example, the G protein-coupled receptors can activate both phosphoinositol and cyclic AMP (cAMP) second messenger pathways. The phosphoinositol pathway is active when the receptor induces...

Korotkoff sounds are the specific sounds heard while measuring blood pressure using a sphygmomanometer, typically with a stethoscope or a Doppler device. They are named after Russian physician Nikolai Korotkov, who first described them in 1905. These sounds correspond to turbulent blood flow in the artery as the blood pressure cuff is gradually released after inflation.
During blood pressure assessment, inflating the cuff 30 millimeters of mercury above the patient's systolic blood pressure...