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Related Experiment Video

Updated: Jul 11, 2026

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Published on: February 10, 2014

Sensor complexes regulating two-component signal transduction.

Hendrik Szurmant¹, Robert A White, James A Hoch

¹The Scripps Research Institute, Division of Cellular Biology, Mail Code: MEM-116, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. szurmant@scripps.edu

Current Opinion in Structural Biology

|October 5, 2007

Summary

Bacteria use complex sensor proteins to detect signals and control gene expression. Understanding these protein structures reveals how bacteria sense their environment and regulate cellular activities.

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Last Updated: Jul 11, 2026

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

Area of Science:

Bacterial physiology
Molecular biology
Signal transduction

Background:

Two-component systems regulate bacterial gene expression in response to environmental cues.
Sensor histidine kinases are key components that receive external signals.

Purpose of the Study:

To investigate the diverse strategies bacteria employ in assembling protein domains into sensor complexes.
To elucidate the mechanisms by which sensor complexes recognize signals and modulate kinase activity.

Main Methods:

Structural studies of protein domains within sensor complexes.
Analysis of protein-ligand interactions and conformational changes.

Main Results:

Identified diverse assembly strategies for protein domains in bacterial sensor complexes.
Structural insights into how sensor complexes recognize signals.

Conclusions:

Bacterial sensor complexes exhibit varied domain architectures for signal interpretation.
Structural biology is crucial for understanding signal recognition and kinase regulation in bacteria.