Related Experiment Video
Updated: Jul 11, 2026

Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses
Published on: October 24, 2019
Androgen-response elements in hormone-refractory prostate cancer: implications for treatment development
Andrew C Hsieh1, Eric J Small, Charles J Ryan
1Department of Medicine, and UCSF Comprehensive Cancer Center, University of California-San Francisco, 94143, USA. andrew.hsieh@ucsf.edu
Identifying genes linked to androgen receptor activity in advanced prostate cancer is crucial for developing new treatments. This research focuses on these genes to improve prognostic and therapeutic strategies for castration-resistant prostate cancer.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Prostate cancer research has sought genetic signatures for prognosis and therapy.
- Existing signatures show heterogeneity and limited reproducibility.
- Understanding androgen receptor-driven genes in advanced prostate cancer is essential.
Purpose of the Study:
- To analyze genes with androgen-response elements in progressive, castration-resistant prostate cancer.
- To identify potential therapeutic and diagnostic targets.
- To explore the clinical potential of androgen receptor downstream targets.
Main Methods:
- Analysis of gene expression patterns in progressive prostate cancer.
- Focus on genes with androgen-response elements.
- Review of downstream targets of the androgen receptor.
Main Results:
- Heterogeneity and limited reproducibility in current genetic signatures.
- Identification of key pathways influenced by androgen receptor targets.
- Discussion of the role of these targets in cancer progression.
Conclusions:
- A disciplined analysis of androgen-responsive genes is vital for prostate cancer research.
- Androgen receptor downstream targets impact proliferation, apoptosis, and angiogenesis.
- Further investigation into these targets may yield new clinical strategies for prostate cancer.
More Related Videos
08:46Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
Published on: December 9, 2015
07:25A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Related Concept Videos
Treatment Resistent Cancers
Mitogens and the Cell Cycle
Treatment Resistant Cancers
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Abnormal Proliferation
Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes: