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[Transient myeloproliferative disorder in a neonate without Down syndrome]
M Adam1, A Vincenot, F Gouraud
1AP-HP, Services d'hématologie biologique et clinique, Hôpital d'enfants Armand Trousseau, Paris.
Abstract:
We report a new case of transient myeloproliferative disorder (TMD) in a non Down syndrome neonate. The cytogenetic and molecular studies within from the blood blast cells identified a trisomy 21 and a partial deletion in exon 2 of the transcription factor GATA1. Spontaneous regression of the TMD was achieved at the age of 1 month as the clonal and molecular abnormalities. A survey by periodic cytological examinations of peripheral blood cells and GATA1 mutation analysis was instituted since three years and has not detected up to date acute leukaemia.
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