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Updated: Jul 11, 2026

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
Published on: March 18, 2021
Late-onset epileptogenesis and seizure genesis: lessons from models of cerebral ischemia
Jérôme Epsztein1, Yehezkel Ben-Ari, Alfonso Represa
1Institut de Neurobiologie de la Méditerranée, Institut National de la Santé et de la Recherche Médicale Unité 29, and Université de La Méditerranée, Marseille Cedex, France.
Abstract:
Patients surviving ischemic stroke often express delayed epileptic syndromes. Late poststroke seizures occur after a latency period lasting from several months to years after the insult. These seizures might result from ischemia-induced neuronal death and associated morphological and physiological changes that are only partly elucidated. This review summarizes the long-term morphofunctional alterations observed in animal models of both focal and global ischemia that could explain late-onset seizures and epileptogenesis. In particular, this review emphasizes the change in GABAergic and glutamatergic signaling leading to hyperexcitability and seizure genesis.
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