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Updated: Jul 11, 2026
09:02
Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
[Current management of the HELLP syndrome]
1Frauenklinik für Gynäkologie und Geburtshilfe, Universitätsklinikum, RWTH Aachen, Aachen, Deutschland.
Gynakologisch-Geburtshilfliche Rundschau
|October 5, 2007
Summary
HELLP syndrome, a serious condition involving hemolysis, elevated liver enzymes, and low platelets, demands prompt diagnosis to prevent rapid deterioration. Differentiating it from similar disorders is crucial for effective management during pregnancy.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Hepatology
Context:
- HELLP syndrome is a critical condition within microangiopathic syndromes, characterized by a rapid clinical decline.
- Accurate diagnosis and differentiation from similar conditions are essential due to potential severe complications.
Purpose:
- To outline the diagnostic and differential diagnostic challenges of HELLP syndrome.
- To detail management strategies across pregnancy phases and discuss therapeutic options.
- To explore prophylaxis for future pregnancies and follow-up care.
Summary:
- HELLP syndrome (hemolysis, elevated liver enzymes, low platelets) requires urgent diagnostic evaluation due to its potential for rapid clinical deterioration.
- Differential diagnosis is complex, distinguishing it from thrombotic-thrombocytopenic purpura, hemolytic-uremic syndrome, and various liver diseases (e.g., acute fatty liver, intrahepatic cholestasis of pregnancy, viral hepatitis).
- The abstract details management strategies throughout pregnancy, therapeutic interventions to prolong gestation, and considerations for subsequent pregnancies and long-term follow-up.
Impact:
- Improved diagnostic accuracy for HELLP syndrome.
- Enhanced patient outcomes through timely and appropriate management strategies.
- Informed clinical decision-making regarding pregnancy and postpartum care for affected individuals.
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