Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ethical decisions on the end of life during internal medicine on-call shifts.

Journal of healthcare quality research·2025
Same author

Should the pharmaceutical industry be involved in continuing medical education?

Revista clinica espanola·2022
Same author

[Genetic evolution of in situ follicular neoplasia to t(14;18)-positive aggressive B-cell lymphoma].

Der Pathologe·2021
Same author

SPARC macrophages in lymphoma.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

Albuminuria and polyvascular disease improve multivariate predictive models after an acute cardiovascular event. The AIRVAG cohort.

Revista clinica espanola·2021
Same author

Areas for improvement in end-of-life care.

Revista clinica espanola·2021

Related Experiment Video

Updated: Jul 11, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Lymphoma microenvironment: culprit or innocent?

B Herreros1, A Sanchez-Aguilera, M A Piris

  • 1Lymphoma Group, Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas (CNIO), Madrid, Spain.

Leukemia
|October 5, 2007
PubMed
Summary

Lymphoid neoplasms rely on their microenvironment for survival and progression. Targeting this microenvironment offers promising new therapeutic strategies for lymphoma.

Area of Science:

  • Oncology
  • Hematology
  • Cell Biology

Background:

  • Lymphoid neoplasms feature chromosome translocations and molecular alterations affecting cell cycle and apoptosis.
  • Tumor cell survival is significantly influenced by interactions within the lymphoma microenvironment.
  • Non-tumor cells provide crucial signals impacting lymphoma initiation and progression.

Purpose of the Study:

  • To review the essential role of the tumor microenvironment in lymphoid neoplasms.
  • To highlight novel therapeutic strategies targeting the lymphoma microenvironment.

Main Methods:

  • Literature review of studies on lymphoid neoplasms and their microenvironment.
  • Analysis of molecular alterations and cellular interactions.
  • Synthesis of evidence on therapeutic approaches targeting the tumor microenvironment.

More Related Videos

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
14:04

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

Published on: March 25, 2016

Related Experiment Videos

Last Updated: Jul 11, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
14:04

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

Published on: March 25, 2016

Main Results:

  • The tumor microenvironment is critical for the initiation and progression of specific lymphoma types.
  • Interactions with non-tumor cells significantly impact lymphoma cell survival.
  • Targeting the microenvironment presents a viable therapeutic avenue.

Conclusions:

  • The lymphoma microenvironment plays an indispensable role in disease pathogenesis.
  • Therapeutic strategies focused on the microenvironment hold significant promise for treating lymphoid neoplasms.