Related Experiment Video
Updated: Jul 11, 2026

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
The future of vaccines in the management of addictive disorders
Frank M Orson1, Berma M Kinsey, Rana A K Singh
1Veterans Administration Medical Center, 2002 Holcombe, Houston, TX 77030, USA. forson@bcm.tmc.edu
Abstract:
Conventional substance abuse treatments have had only limited success. As a result, new approaches, including vaccination to block the effects of drugs such as cocaine, nicotine, methamphetamine, and phencyclidine, are in development. Although a number of possible rationales for the effects of antidrug vaccines have been suggested, the most straightforward and intuitive mechanism would involve binding of the drug by antibodies in the bloodstream, thereby blocking entry or reducing the rate of entry of the drug into the central nervous system. The theoretical parameters that would influence vaccine-induced drug pharmacodynamics are presented in this review, along with the current status on vaccine development for nicotine, cocaine, methamphetamine, and phencyclidine.
More Related Videos
08:22Stereotaxic Microinjection of Viral Vectors Expressing Cre Recombinase to Study the Role of Target Genes in Cocaine Conditioned Place Preference
Published on: July 30, 2013
07:31Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
Related Concept Videos
Drug Abuse and Addiction: Pharmacological Phenomena
Drug Dependence
Microorganisms in Medicine and Therapeutics
Vaccinations
Pharmaceutical Poisoning: Treatment Strategies
Vaccines