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Updated: Jul 11, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
16:07

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method

Published on: September 16, 2017

[Biological therapy with anti-TNF antibodies. Extending the spectrum of its indications?]

M López Rodríguez1, M García Arias, J Gómez Cerezo

  • 1Servicio de Medicina Interna. Hospital Universitario La Paz. Madrid. España. monlr2001@hotmail.com

Revista Clinica Espanola
|October 5, 2007
PubMed

Tumor necrosis factor (TNFalpha) is a main mediator in the inflammatory answer of many diseases. The anti-TNFalpha antibodies (infliximab, etanercept, adalimumab) block their action, preventing the inflammatory answer and the damage it produces. In this paper, we review the treatment of some diseases in which these drugs are experimentally used. These are: ulcerative colitis, sarcoidosis, graft-versus-host disease, adult Still's disease, some systemic vasculitis, systemic lupus erythematosus and Behçet disease.

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