[Features of ontogenesis of uroliths]

The aim of the study was investigation of urolith growth process using the method of ontogenetic analysis. A total of 435 autochtonic uroliths obtained after surgery or spontaneous elimination from 422 patients with urolithiasis were studied with roentgenophasic analysis on diffractometer DRON-3, IR-spectroscopy, electron-probe. The concrements incorporate several zones with a nucleus as one of the zones. In some cases spherolith consisted of several splitted individuums with different orientation. Their nuclei contained phosphates and organic substance resultant from renal inflammation. In the other cases lithogenesis of the spherolith started from monocrystal microscopic nucleus which arrived from the kidney. The number of spherolith emergences can be interpreted as a rhythmic course of the disease. A prolonged macrorhythm characterizes stable disease. Formation of cut surfaces of the spherolith defines interruption of rhythmic zonality. A change in the composition of the crystal medium does not stop concrement growth, it provokes replacement of one mineral phase for the other. The ontogenetic analysis has detected that in the position of the concrement in the kidney mineral substance of its deep zones undergoes phasic transformations and morphological alterations. In changing medium conditions there are recovery of surfaces of solution with a change of a mineral phase, formation of new growth rhythms, aggregation and compression of the particles. This explains mixed composition of most of uroliths.