Related Experiment Video
Updated: Jul 11, 2026
10:10
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Compressed matrix core tablet as a quick/slow dual-component delivery system containing ibuprofen
Carla Martins Lopes1, José M Sousa Lobo, João F Pinto
1Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal. clopes@ff.up.pt
AAPS Pharmscitech
|October 6, 2007
Summary
This study developed a biphasic drug delivery system for ibuprofen using a dual-component tablet. The system provides rapid release from the coat and sustained release from the core, achieving controlled ibuprofen delivery.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Developing effective drug delivery systems is crucial for optimizing therapeutic outcomes.
- Biphasic drug release offers a promising approach for managing drug concentrations over time.
Purpose of the Study:
- To engineer a novel biphasic delivery system for ibuprofen.
- To achieve both immediate and sustained release of ibuprofen from a single dosage form.
Main Methods:
- Fabrication of a dual-component tablet (sustained-release core, immediate-release coat) via direct compression.
- Incorporation of ibuprofen as a model drug in both core and coat.
- Utilizing polymers like hydroxypropyl methylcellulose (HPMC) or ethylcellulose to control drug release from the core.
Main Results:
- The developed system demonstrated biphasic ibuprofen release in vitro.
- Immediate release component dissolved ibuprofen within 2 minutes.
- Sustained release core provided drug release over 16 to >24 hours, dependent on polymer composition.
Conclusions:
- The biphasic system successfully achieved the desired quick/slow release profile for ibuprofen.
- Hydroxypropyl methylcellulose (HPMC) based core matrices are effective for achieving zero-order, sustained drug release over extended periods.
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