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Updated: Jul 11, 2026

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
Published on: August 28, 2015
Copolymers including L-histidine and hydrophobic moiety for preparation of nonbiofouling surface
Takehiko Ishii1, Akira Wada, Saki Tsuzuki
1Nano Medical Engineering Laboratory, RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama, Japan.
Abstract:
A new type of copolymer composed of l-histidine (ampholyte) and n-butyl methacrylate (hydrophobic moiety) was developed for the preparation of nonbiofouling surfaces. The copolymer adsorbed onto resin surfaces and made the surface very hydrophilic. The hydrophilization effect was higher than that of bovine serum albumin (BSA). When polystyrene surfaces were coated with the copolymer, both the nonspecific adsorption of protein and the adhesion of cells were significantly reduced in comparison with BSA coating. The newly synthesized polymer is a new and useful candidate for the preparation of nonbiofouling surfaces.

