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Related Experiment Video

Updated: Jul 11, 2026

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis
04:47

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

Ankylosing spondylitis: an Australian experience.

M D Reed1, S Dharmage, A Boers

  • 1Department of Rheumatology, Royal Perth Hospital, Perth, Western Australia, Australia.

Internal Medicine Journal
|October 6, 2007
PubMed
Summary

Ankylosing spondylitis (AS) diagnosis delays averaged 8.1 years, particularly in women. Women showed better mobility but worse quality of life, indicating unique disease patterns in this Australian cohort.

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Area of Science:

  • Rheumatology
  • Clinical Epidemiology
  • Immunology

Background:

  • Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton.
  • Understanding the characteristics of specific patient cohorts is crucial for improving disease management.
  • Previous studies have described AS patient populations, but Australian cohorts require specific characterization.

Purpose of the Study:

  • To characterize an Australian cohort of ankylosing spondylitis (AS) patients.
  • To identify predictors of key disease outcomes in this population.
  • To compare findings with previously described international cohorts.

Main Methods:

  • A cross-sectional study design was employed, analyzing data from the first visit of patients referred to the Austin Spondylitis Clinic.

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  • Clinical and laboratory data were collected.
  • Validated composite indices were assessed using self-reported questionnaires.

    • Main Results:

    • The average delay in diagnosis for ankylosing spondylitis (AS) was 8.1 years, with longer delays observed in women and those with younger onset.
    • Women exhibited better cervicothoracic mobility but reported more entheseal tender points and a greater impairment in quality of life.
    • Long-standing AS patients demonstrated similar disease activity to recent-onset cases but experienced greater functional disability. Current smoking correlated with worse outcomes.

    Conclusions:

    • The clinical presentation of ankylosing spondylitis (AS) in this Australian cohort aligns with findings from other international studies.
    • Women presented with greater cervicothoracic mobility and a higher enthesitis index, potentially contributing to diagnostic delays.
    • These findings highlight sex-based differences in AS clinical expression and underscore the need for timely diagnosis and tailored management strategies.