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[Persistent central diabetes insipidus in a very low birth weight infant]

F Quetin1, H Garnier, R Brauner

  • 1Service de réanimation néonatale, institut de puériculture et de périnatalité, 26, boulevard Brune, 75014 Paris, France. ipp.quetin@free.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|October 6, 2007
PubMed

Insights

Central diabetes insipidus (DI) is rare in newborns. This case study shows successful treatment of idiopathic DI in a premature infant using oral desmopressin, with low doses maintained after discharge.

Area of Science:

  • Neonatal Medicine
  • Pediatric Endocrinology
  • Rare Diseases

Background:

  • Central diabetes insipidus (DI) is uncommon in neonates, often linked to identifiable causes.
  • Desmopressin is an effective treatment, but requires individualized dosing via nasal or oral routes.

Observation:

  • A case of idiopathic central DI is presented in a very low birth weight infant within the first month of life.

Findings:

  • Successful management of neonatal central DI was achieved using oral desmopressin.
  • Low-dose oral desmopressin therapy was continued post-discharge, demonstrating sustained efficacy.

Implications:

  • This case highlights the feasibility of oral desmopressin for treating neonatal idiopathic central DI.
  • Individualized, low-dose desmopressin therapy can be a viable long-term treatment option for affected infants.

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