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Effect of homocysteine on bone mineral density of rats
Feray Soyupek1, Sureyya Cerci, Sedat Yildiz
1Department of Physical Medicine and Rehabilitation, Süleyman Demirel University School of Medicine, Isparta 32260, Turkey. feraysoyupek@yahoo.com
Abstract:
The relationship between plasma levels of homocysteine (Hcy) and femur bone mineral density (BMD) was studied in Wistar rats. After 8 weeks of treatment with 0.5 and 1.0 g kg(-1) day(-1) l-methionine the mean plasma levels of Hcy were 7.67 +/- 1.25 and 61.2 +/- 11.4 micromol/l, respectively. Only rats treated with the higher dose had Hcy levels significantly higher than those of controls, 6.38 +/- 0.90 micromol/l (p < 0.001). Dual Energy X-ray Absorptiometry was used to measure the BMD, which was significantly lower only in the animals with the highest plasma levels of Hcy (p < 0.001). This led us to conclude that increased levels of Hcy are associated with risk of decreased BMD.
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