Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD8 T cell memory development: CD4 T cell help is appreciated.

Aaruni Khanolkar1, Vladimir P Badovinac, John T Harty

  • 1Department of Microbiology, University of Iowa, 3-512 Bowen Science Building, Iowa City, IA 52242, USA.

Immunologic Research
|October 6, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mapping self-associating chromatin hubs identifies Id proteins as key determinants of exhausted CD8<sup>+</sup> T cell fate.

Nature immunology·2026
Same author

Exhausted CD8<sup>+</sup> T cell fate is programmed by dynamic CTCF-mediated enhancer activation and invariant CTCF-imposed barriers.

Nature immunology·2026
Same author

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience.

Cytometry. Part B, Clinical cytometry·2026
Same author

Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy.

The Journal of clinical investigation·2026
Same author

Case Report: Novel <i>MAGT1</i> pathogenic variant with significant atopy, hypogammaglobulinemia and viral skin infections.

Frontiers in immunology·2026
Same author

mRNA vaccination overcomes haemozoin-mediated impairment of whole-parasite malaria vaccines in mice.

Nature microbiology·2026

Understanding how CD8 T cells become long-lasting memory cells is crucial for effective vaccines. Research is exploring the role of CD4 T cells in this critical immune system transition.

Area of Science:

  • Immunology
  • Vaccinology
  • Cellular Biology

Background:

  • Long-term immunity is a key goal of vaccination.
  • CD8 T cells are vital for eradicating pathogens and forming immune memory.
  • The transition of CD8 T cells into memory cells is not fully understood.

Purpose of the Study:

  • To investigate the factors regulating the development of memory CD8 T cells.
  • To clarify the role of CD4 T cells in CD8 T cell memory formation and function.

Main Methods:

  • This study focuses on the immunological mechanisms underlying T cell memory.
  • Specific methods are not detailed in the abstract, but the research investigates cellular interactions.

Main Results:

Related Experiment Videos

  • CD4 T cells are essential for the survival and function of memory CD8 T cells.
  • The precise mechanisms of CD4 T cell influence on CD8 T cell memory remain unclear.

    • Conclusions:

    • Further research is needed to elucidate the interaction between CD4 and CD8 T cells for robust immune memory.
    • Understanding these cellular dynamics can inform the development of improved vaccination strategies.