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Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
Published on: October 26, 2018
[Development of multifunctional envelope type artificial viral-like gene delivery system]
Hideyoshi Harashima1, Kentaro Kogure, Yuma Yamada
1Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo 060-0812, Japan. harasima@pharm.hokudai.ac.jp
Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|October 6, 2007
Summary
This review presents Programmed Packaging for non-viral gene delivery using multifunctional envelope type nano devices (MEND). It highlights controlled intranuclear disposition as key for safe and efficient gene delivery systems.
Area of Science:
- Biotechnology
- Nanotechnology
- Molecular Biology
Context:
- Gene delivery systems are crucial for genetic therapies.
- Non-viral vectors offer a safer alternative to viral vectors but face efficiency challenges.
- Understanding intracellular trafficking is vital for optimizing gene delivery.
Purpose:
- Introduce the novel concept of "Programmed Packaging" for non-viral gene delivery.
- Describe the development and application of multifunctional envelope type nano devices (MEND).
- Analyze the rate-limiting steps in intracellular trafficking for viral and non-viral vectors.
Summary:
- Programmed Packaging is a new concept for designing non-viral gene delivery systems.
- Multifunctional envelope type nano devices (MEND) were engineered for in vitro, in situ, and in vivo applications.
- Quantitative studies revealed that controlled intranuclear disposition is critical for safe and efficient non-viral gene delivery.
Impact:
- Provides a future direction for the development of advanced non-viral gene delivery systems.
- Offers insights into optimizing gene delivery by addressing intracellular trafficking barriers.
- Facilitates the advancement of genetic medicine through improved vector design.