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Updated: Jul 11, 2026
10:21
Protein Target Prediction and Validation of Small Molecule Compound
Published on: February 23, 2024
[Structural and functional studies on proteins as potential drug discovery targets]
1School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. ntanaka@pharm.showa-u.ac.jp
Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|October 6, 2007
Summary
This study uses structural biology to investigate human disease proteins and pathogen growth factors, including autocrine motility factor, ribonuclease L, and Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase.
Area of Science:
- Structural biology
- Protein structure and function
- Drug discovery
Context:
- Structural biology is key to understanding biological molecules.
- Drug design is a primary medical application of structural biology.
- Research focuses on human disease proteins and pathogen-essential proteins.
Purpose:
- To perform structural and functional studies on key proteins.
- To investigate human autocrine motility factor.
- To analyze human ribonuclease L and Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase.
Summary:
- Detailed structural and functional analyses of human autocrine motility factor.
- Elucidation of the structure and function of human ribonuclease L.
- Investigation of Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase structure and function.
Impact:
- Provides foundational structural data for potential drug targets.
- Advances understanding of human disease mechanisms.
- Offers insights into pathogenic organism biology for therapeutic development.
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