Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Skeletal muscle remodeling.

Matthew J Potthoff1, Eric N Olson, Rhonda Bassel-Duby

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148, USA.

Current Opinion in Rheumatology
|October 6, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precision modification of heart failure signaling by CRISPR-Cas9 base editing.

Journal of molecular and cellular cardiology·2026
Same author

A human cardiomyocyte screen identifies optimized lipid nanoparticles for in vivo cardiac gene editing.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Nrf1 coordinates proteasome activity and autophagy to maintain cardiac proteostasis.

Communications biology·2026
Same author

Ablation of PKCα Phosphorylation by CRISPR-Cas9 Base Editing Rescues Heart Failure.

Circulation research·2026
Same author

Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells.

Stem cell reports·2025
Same author

Precise gene editing of pathogenic Lamin A mutations corrects cardiac disease.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same journal

New approaches to the management of cutaneous lupus.

Current opinion in rheumatology·2026
Same journal

"Updates in chronic nonbacterial osteomyelitis: emerging insights across the age spectrum".

Current opinion in rheumatology·2026
Same journal

Difficult-to-treat, complex-to-manage, treatment-refractory spondyloarthritis: semantics or substance?

Current opinion in rheumatology·2026
Same journal

Update on IgA nephropathy: implications for treatment in IgA vasculitis: a guide for rheumatologists.

Current opinion in rheumatology·2026
Same journal

Polyarticular juvenile idiopathic arthritis: insights from genetic studies on disease risk and pathogenesis.

Current opinion in rheumatology·2026
Same journal

Immune dysregulation in children with Down syndrome: clinical implications and emerging therapies.

Current opinion in rheumatology·2026
See all related articles

Targeting skeletal muscle signaling pathways and microRNAs offers new therapeutic strategies for muscle diseases. These approaches aim to remodel myofibers, enhance muscle function, and combat pathology for improved clinical outcomes.

Area of Science:

  • Muscle physiology and molecular biology
  • Signal transduction in skeletal muscle
  • Therapeutic applications in myopathies

Background:

  • Environmental stimuli trigger signaling pathways in skeletal muscle, leading to adaptive changes in myofiber structure and protein content.
  • Understanding these pathways is crucial for developing novel therapeutic interventions for muscle remodeling.

Purpose of the Study:

  • To review recent advances in identifying signaling factors involved in skeletal muscle remodeling.
  • To explore potential therapeutic strategies targeting these pathways and related molecular regulators.

Main Methods:

  • Utilizing genetic engineering and transgenic mouse models to manipulate signaling factors within myofibers.
  • Employing global gene and protein expression profiling to discover novel factors in muscle remodeling.

Related Experiment Videos

  • Investigating the role of microRNAs (miRNAs) as regulators of gene expression in skeletal muscle.

    • Main Results:

    • Activation of specific signaling pathways in mouse models enhanced muscle characteristics like fatigue resistance and mass, and improved injury outcomes.
    • New technologies are identifying previously unknown factors influencing skeletal muscle remodeling.
    • MicroRNAs are identified as potent regulators of gene expression with significant therapeutic potential.

    Conclusions:

    • Targeting signaling pathways with drugs presents a viable therapeutic avenue for skeletal muscle diseases.
    • Genome-wide technologies can yield biomarkers for diagnosing myopathies and monitoring treatment efficacy.
    • Therapeutic strategies focusing on microRNAs show promise in reversing gene repression associated with muscle pathology.