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Adipose tissue formation in response to basic fibroblast growth factor.

Etsuyo Tamura1, Hiroyuki Fukuda, Yasuhiko Tabata

  • 1Department of Otorhinolaryngology, Tokai University School of Medicine, Tokai University Tokyo Hospital, Tokyo, Japan. otamura@tok.u-tokai.ac.jp

Acta Oto-Laryngologica
|October 6, 2007
PubMed
Summary

Basic fibroblast growth factor (bFGF) may promote new fat cell formation in injected adipose tissue. This approach helps maintain injected fat volume, unlike fat injections alone.

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Area of Science:

  • Regenerative Medicine
  • Adipose Tissue Engineering
  • Vocal Cord Surgery

Background:

  • Autologous fat injection is used to restore vocal cord volume after paralysis.
  • Fat grafting often results in significant volume loss over time.
  • Basic fibroblast growth factor (bFGF) is investigated for its potential role in tissue regeneration.

Purpose of the Study:

  • To evaluate the effect of basic fibroblast growth factor (bFGF) on the survival and volume maintenance of autologous fat injected into vocal cords.
  • To assess the potential for new adipose tissue generation in response to bFGF combined with fat grafting.

Main Methods:

  • Bilateral recurrent laryngeal nerve paralysis models were created in 12 beagle dogs.
  • Autologous fat was injected into one vocal cord.
  • A mixture of autologous fat with bFGF, gelatin microspheres, and collagen sponge was injected into the contralateral vocal cord.
  • Histological examination of injected tissues was performed over 24 weeks.

Main Results:

  • Vocal cords injected with fat and bFGF showed the presence of immature adipocytes at 8 weeks.
  • The volume of injected fat was well-maintained up to 24 weeks when bFGF was included.
  • Vocal cords receiving only autologous fat exhibited significant volume reduction over time.

Conclusions:

  • Basic fibroblast growth factor (bFGF) appears to promote the formation of new fat cells within injected adipose tissue.
  • Combining bFGF with autologous fat injections may improve long-term fat graft survival and volume maintenance in vocal cords.