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A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Treatment differences in cases with venous angioma
Salih Gülşen1, Nur Altinörs, Başar Atalay
1Başkent University, School of Medicine, Department of Neurosurgery, Bahçelievler, Ankara, Turkey. gulsen.salih@gmail.com
Venous angiomas are common cerebral vascular malformations with a low annual bleeding risk. This report details two cases, highlighting varied presentations and management considerations for these typically silent lesions.
Area of Science:
- Neurology
- Vascular Malformations
- Cerebral Anatomy
Background:
- Venous angiomas are the most frequent cerebral vascular malformations, accounting for 63% of lesions in autopsy studies.
- These low-flow, low-pressure vascular structures typically drain normal brain tissue and are often asymptomatic.
- The annual bleeding risk associated with venous angiomas is approximately 0.22%.
Observation:
- This paper presents two distinct cases of venous angiomas.
- The first case involved a posterior fossa venous angioma that bled twice within a short period.
- The second case involved a patient with a history of warfarin treatment who experienced a cerebral stroke near the caudate nucleus, unrelated to an incidentally discovered venous angioma in the same region.
Findings:
- Venous angiomas, despite being common and generally silent, can present with serious complications such as bleeding and stroke.
- Conservative management may be suitable for asymptomatic or mildly symptomatic patients.
- The presence of venous angiomas, even when seemingly unrelated to acute events like stroke, requires careful consideration, especially in patients on anticoagulant therapy.
Implications:
- Increased awareness and diagnostic vigilance for venous angiomas are crucial, particularly in patients with neurological symptoms or those on anticoagulant therapy.
- Further research into the natural history and optimal management strategies for venous angiomas is warranted.
- Understanding the diverse clinical manifestations of venous angiomas can improve patient outcomes and inform treatment decisions.
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