Related Experiment Video
Updated: Jul 11, 2026

Grade III Varicocele Surgical Treatment using Spermatic Vein-Superficial Abdominal Vein Shunt
Published on: August 23, 2024
[Influence of varicocele on sperm chromatin structure and sperm motility]
Jie Tang1, Su-wen Yan, Ning Zhang
1Reproduction Centre, the 202nd Hospital of PLA, Shenyang, Liaoning 110003, China. yicongtang@hotmail.com
Objective:
To study the influence of varicocele on sperm chromatin structure and sperm motility.
Methods:
Routine semen analysis and sperm chromatin structure assay (SCSA) were performed in a varicocele group (n=74) and a control group (n=89).
Results:
Sperm concentration (41.4 +/- 38.7] x 10(6)/ml) grade a+b sperm percentage ([31.7 +/- 16.9]% and sperm viability ([62.8 +/- 22.2]%) in the varicocele group were evidently lower than those ([80.9 +/- 63.1] x 10(6)/ml, [46.8 +/- 20.5]%, [77.2 +/- 17.5])% in the control group (P < 0.05) and so were VCL, VSL and VAP ([37.4 +/- 12.5 microm/s, [23.4 +/- 7.8] microm/s, [26.5 +/- 8.2] microm/s) in the varicocele group than those ([42.4 +/- 10.7] microm/s, [27.3 +/- 7.3] microm/s, [30.7 +/- 7.8] microm/s) in the control (P < 0.05). MAD was increased (P < 0.01), and the COMP alphat of SCSA (23.2 +/-16.2) was obviously higher in the former than in the latter (14.1 +/- 11.8) (P < 0.05).
Conclusion:
Varicocele causes damage to sperm DNA and changes sperm motility, which may result in male infertility.
Related Concept Videos
Sperm Structure and Semen Composition
Spermatogenesis
Spermatogenesis
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
Infertility in Males
Sperm Transport
The maturation phase occurs in the epididymis, where sperm...
Position-effect Variegation

