Formulating poly(lactide-co-glycolide) particles for plasmid DNA delivery
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PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
Published on: December 27, 2013
Aiman O Abbas1, Maureen D Donovan, Aliasger K Salem
1Division of Pharmaceutics, College of Pharmacy, University of Iowa, S228 Pharmacy Building, 115 S Grand Avenue, Iowa City, Iowa 52242, USA.
Journal of Pharmaceutical Sciences
|October 9, 2007
Abstract:
Biodegradable poly(lactide-co-glycolide) (PLGA) particles have shown significant potential for sustained and targeted delivery of several pharmaceutical agents, including plasmid DNA (pDNA). Here, we survey current approaches to PLGA particle preparation for pDNA delivery and discuss recent progress on optimizing formulation development.

