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Formulating poly(lactide-co-glycolide) particles for plasmid DNA delivery
Aiman O Abbas1, Maureen D Donovan, Aliasger K Salem
1Division of Pharmaceutics, College of Pharmacy, University of Iowa, S228 Pharmacy Building, 115 S Grand Avenue, Iowa City, Iowa 52242, USA.
Journal of Pharmaceutical Sciences
|October 9, 2007
Summary
Biodegradable poly(lactide-co-glycolide) (PLGA) particles offer promising sustained and targeted delivery for pharmaceutical agents like plasmid DNA (pDNA). This review covers PLGA particle preparation methods and formulation optimization for effective pDNA delivery.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Biodegradable poly(lactide-co-glycolide) (PLGA) nanoparticles are advanced drug delivery systems.
- PLGA particles are effective for delivering various pharmaceutical agents, including plasmid DNA (pDNA).
Purpose of the Study:
- To survey current preparation methods for PLGA particles designed for pDNA delivery.
- To discuss recent advancements in optimizing PLGA-pDNA formulation development.
Main Methods:
- Literature review of PLGA particle preparation techniques.
- Analysis of formulation strategies for enhancing pDNA encapsulation and release.
Main Results:
- PLGA particles demonstrate significant potential for sustained and targeted pDNA delivery.
- Ongoing research focuses on optimizing PLGA formulations for improved therapeutic efficacy.
Conclusions:
- PLGA particles represent a viable platform for advanced pDNA delivery systems.
- Further optimization of formulation development is crucial for maximizing the therapeutic benefits of PLGA-pDNA formulations.
