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Related Concept Videos

Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.

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Updated: Jul 11, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
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Published on: January 26, 2024

Adiponectin in severe preeclampsia.

Jyh Kae Nien1, Shali Mazaki-Tovi, Roberto Romero

  • 1Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, USA.

Journal of Perinatal Medicine
|October 9, 2007
PubMed
Summary

Maternal plasma adiponectin concentrations are higher in severe preeclampsia. This may indicate a compensatory mechanism in response to the condition's metabolic and angiogenic changes.

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Last Updated: Jul 11, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

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Published on: January 26, 2024

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Area of Science:

  • Endocrinology
  • Obstetrics
  • Cardiovascular Research

Background:

  • Adiponectin, an adipokine, possesses insulin-sensitizing, anti-atherogenic, anti-inflammatory, and angiogenic properties.
  • Severe preeclampsia is a pregnancy complication with significant metabolic and vascular alterations.

Purpose of the Study:

  • To compare maternal plasma adiponectin concentrations in severe preeclampsia versus normal pregnancies.
  • To investigate the association between plasma adiponectin and uterine artery Doppler velocimetry findings.

Main Methods:

  • A case-control study involving 50 women with severe preeclampsia and 150 with normal pregnancies.
  • Plasma adiponectin levels were measured using ELISA.
  • Uterine artery Doppler ultrasound was performed.

Main Results:

  • Median plasma adiponectin was significantly higher in women with severe preeclampsia.
  • No significant difference in adiponectin was observed based on uterine artery blood flow impedance in preeclampsia.
  • In normal pregnancies, adiponectin correlated negatively with BMI.

Conclusions:

  • Elevated maternal plasma adiponectin is characteristic of severe preeclampsia.
  • This elevation might represent a compensatory response to the pro-atherogenic and anti-angiogenic state of severe preeclampsia.