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Related Experiment Video

Updated: Jul 11, 2026

Colletotrichum fioriniae Development in Water and Chloroform-based Blueberry and Cranberry Floral Extracts
12:32

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Published on: April 12, 2019

Interaction between warfarin and cranberry juice.

Christine H Paeng1, Michael Sprague, Cynthia A Jackevicius

  • 1Coflege of Pharmacy, Western University of Health Sciences, Pomona, California 91766-1854, USA.

Clinical Therapeutics
|October 9, 2007
PubMed
Summary

This case report highlights a potential interaction between warfarin and cranberry juice. Consuming cranberry juice may increase the international normalized ratio (INR) in patients taking warfarin, necessitating careful monitoring.

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Area of Science:

  • Pharmacology
  • Clinical Medicine

Background:

  • Warfarin is a widely prescribed anticoagulant for preventing thromboembolic events.
  • A potential interaction between warfarin and cranberry juice has been suggested but is infrequently reported.

Observation:

  • An elderly male patient on warfarin for atrial fibrillation presented with a significantly elevated international normalized ratio (INR) of 6.45.
  • The patient reported consuming a half gallon of cranberry/apple juice in the week preceding the elevated INR.
  • Discontinuation of cranberry juice and a slight warfarin dose adjustment normalized the INR to the therapeutic range.

Findings:

  • Cranberry juice ingestion was identified as the most probable cause of the elevated INR.
  • The Naranjo probability scale indicated a possible interaction (score 3), while a modified scale for anticoagulants rated it as probable (score 5).
  • The interaction resulted in an elevated INR without associated bleeding complications.

Implications:

  • This case underscores the importance of considering cranberry juice as a potential interacting agent in patients taking warfarin.
  • Healthcare providers should counsel patients on potential dietary interactions with anticoagulants.
  • Further research may be warranted to elucidate the mechanisms and clinical significance of the warfarin-cranberry juice interaction.