Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A prospective risk analysis for the clinical commissioning of a dose-driven continuous scanning proton therapy system.

Frontiers in oncology·2026
Same author

A feasibility study on a machine-learning-based quality assurance tool for spot-scanning proton therapy using delivery log files and treatment plans.

Physics and imaging in radiation oncology·2026
Same author

Outcomes of stereotactic body radiotherapy for supraclavicular lymph node metastasis among patients with metastatic prostate cancer.

Clinical and translational radiation oncology·2026
Same author

Designing a Collaborative Immersive Visualization System for Radiation Treatment Planning Teams.

IEEE transactions on visualization and computer graphics·2026
Same author

Reducing pitfalls in composite plan evaluations of dose-weighted linear energy transfer (LETd) through a field-by-field approach.

Physics in medicine and biology·2026
Same author

Deep learning-based dose prediction for prostate cancer with empty bladder protocol: a framework for efficient and personalized radiotherapy planning.

Frontiers in oncology·2026

Related Experiment Video

Updated: Jul 11, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Planning target margin calculations for prostate radiotherapy based on intrafraction and interfraction motion using

Chris Beltran1, Michael G Herman, Brian J Davis

  • 1Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, MN, USA. chris.beltran@stjude.org

International Journal of Radiation Oncology, Biology, Physics
|October 9, 2007
PubMed
Summary

Using implanted gold seeds for prostate radiotherapy localization significantly reduces planning target volume (PTV) margins compared to skin marks. Intrafractional motion remains a key factor limiting further margin reduction.

More Related Videos

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

Related Experiment Videos

Last Updated: Jul 11, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Prostate Cancer Treatment

Background:

  • Accurate patient positioning is crucial in radiotherapy to minimize radiation dose to healthy tissues.
  • Prostate motion during treatment can be attributed to interfractional (setup) and intrafractional (internal) components.
  • Traditional localization methods like skin marks may not adequately account for prostate motion, necessitating larger planning target volume (PTV) margins.

Purpose of the Study:

  • To determine optimal planning target volume (PTV) margins for prostate radiotherapy.
  • To evaluate the impact of different daily localization methods on PTV margins, considering internal margin (IM) and setup margin (SM).
  • To compare PTV margins derived from skin marks, bony anatomy, and intraprostatic gold seeds with varying thresholds.

Main Methods:

  • Forty prostate cancer patients underwent external beam radiotherapy with online image guidance.
  • Intraprostatic gold seeds and electronic portal images (EPIs) were used for daily localization.
  • Interfractional and intrafractional prostate motion were analyzed to determine setup margins (SM) and internal margins (IM) for four localization techniques.

Main Results:

  • Tattoo localization required substantial SM: 6.8 mm (LR), 7.2 mm (IS), 9.8 mm (AP).
  • Localization using intraprostatic gold seeds with a 5-mm threshold resulted in significantly reduced SM (4.0 mm LR, 3.9 mm IS, 3.7 mm AP).
  • The PTV margin with the 5-mm threshold method was 4.8 mm (LR), 5.4 mm (IS), and 5.2 mm (AP), while intrafractional motion required an IM of 2.4 mm (LR) and 3.4 mm (IS/AP).

Conclusions:

  • Intraprostatic gold seed localization with EPI significantly reduces PTV margins compared to skin mark-based methods.
  • Bony anatomy localization offered limited margin reduction, except in the left-right direction.
  • Intrafractional prostate motion remains a critical factor influencing the achievable reduction in PTV margins.