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Toshio Okamoto1, Satoru Takahashi, Eiki Nakamura

  • 1Department of Pediatrics, Asahikawa Medical College, Asahikawa Kosei Hospital, Hokkaido 078-8510, Japan. toshio5p@asahikawa-med.ac.jp

Early Human Development
|October 9, 2007
PubMed

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Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
A...