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Updated: Jul 11, 2026

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
Published on: July 25, 2019
Ubiquitin-mediated proteasomal degradation in normal and malignant hematopoiesis
Mélina L Heuzé1, Isabelle Lamsoul, Christel Moog-Lutz
1Institut de Pharmacologie et de Biologie Structurale, UMR 5089 CNRS, Université Paul Sabatier, 205 Route de Narbonne, F-31077 Toulouse, France.
Abstract:
Understanding the molecular mechanisms controlling normal hematopoietic differentiation is critical to develop new treatments for blood diseases and to manipulate stem cells. Despite the identification of many players in hematopoiesis, the molecular mechanisms controlling hematopoietic differentiation remain poorly understood. Due to a number of recent findings, the targeting of regulators of hematopoiesis to proteasomal degradation might be an important step in control of this developmental program.
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